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KMID : 0043319980210010017
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Archives of Pharmacal Research
1998 Volume.21 No. 1 p.17 ~ p.23
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Intestinal Bacterial Metabolism of Flavonoids and Its Relation to Some Biological Activities
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Kim Dong-Hyun
Jung Eun-Ah
Sohng In-Suk
Han Jung-Ah
Kim Tae-Hyung
Han Myung-Joo
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Abstract
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Flavonoid glycosides were metabolized to phenolic acids via aglycones by human intestinal microflora producing -rhamnosidase, exo--glucosidase, endo- -glucosidase and/or -glucuronidase. Rutin, hesperidin, naringin and poncirin were transformed to their aglycones by the bacteria producing -rhamnosidase and -glucosidase or endo- -glucosidase, and baicatin, puerarin and daidzin were transformed to their aglycones by the bacteria producing glucuronidase, C-glycosidase and -glycosidase, respectively. Anti-platelet activity and cytotoxicity of the metabolites of flavonoid glycosides by human intestinal bacteria were more effective than those of the parental compounds. 3,4-Dihydroxyphenylacetic acid and 4-hydroxyl-phenylacetic acid were more effective than rutin and quercetin on anti-platelet aggregation activity. 2,4,6-Trihydroxybenzaidehyde, quercetin and ponciretin were more effective than rutin and ponciretin on the cytotoxicity for tumor cell lines. We insist that these flavonoid glycosides should be natural prodrugs.
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KEYWORD
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Intersinal bacerial metabolism, Flavonoids, Flavonoid glycosides
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